Guest Speakers

Prof Fred Gage - Salk Institute - La Jolla, California, USA

  • Dr. Gage is the Adler Professor in the Laboratory of Genetics, and immediate past President of the Salk Institute, and an Adjunct Professor, UCSD. He received his Ph.D. from The Johns Hopkins University. Dr. Gage's work concentrates on the adult central nervous system and unexpected plasticity and adaptability to environmental stimulation that remains throughout the life of all mammals. In addition, he models human neurological and psychiatric disease in vitro using human stem cells. His lab also studies the genomic mosaicism that exists in the brain as a result of mobile elements that are active during neurogenesis.

    Dr. Gage is a Fellow of the AAAS, a Member of the National Academy of Sciences and the National Academy of Medicine, and American Philosophical Society, a foreign member of the EMBO and a Member of the American Academy of Arts and Sciences.He served as President of the Society for Neuroscience in 2002, and of the International Society for Stem Cell Research in 2012.

Prof Ed Lein - Allen Institute - Seattle, USA

  • Ed Lein is a Senior Investigator at the Allen Institute for Brain Science and an Affiliate Professor in the Departments of Neurological Surgery and Laboratory Medicine and Pathology (DLMP) at the University of Washington. He received a B.S. in biochemistry from Purdue University and a Ph.D. in neurobiology from UC Berkeley and performed postdoctoral work at the Salk Institute for Biological Studies. Ed joined the Allen Institute in 2004 and has provided scientific leadership for the creation of large-scale anatomical, cellular and gene expression atlases of the adult and developing mammalian brain as catalytic community resources, including the inaugural Allen Mouse Brain Atlas and a range of developmental and adult human and nonhuman

    primate brain atlases. Particular current research interests involve the use of single cell genomics as a core phenotype to understand brain cellular organization, mammalian conservation and human specificity, define cellular vulnerability in disease, and identify regulatory elements that allow cell type-specific targeting and

    Manipulation. He leads the Human Cell Types Department, which aims to create comprehensive cell atlases of the human and non-human primate brain, understand what is disrupted in Alzheimer’s disease, and create tools for precision genetic targeting of brain cell types as transformative tools for basic neuroscience and gene therapy. He is also a member of the BRAIN Initiative Cell Atlas Network (BICAN), a member of the Organizing Committee of the Human Cell Atlas (HCA), and a CIFAR fellow. Ed's areas of expertise include developmental neurobiology, structural

    and cellular neuroanatomy, transcriptomics and epigenomics, comparative neurobiology, and Alzheimer’s disease. His research program work encompasses brain cell atlasing, comparative neurobiology, Alzheimer’s disease, and gene therapy.

A/Prof Tomasz Nowakowski - UCSF - San Francisco, USA

  • Dr. Tom Nowakowski is an Associate Professor of Neurological Surgery at the University of California, San Francisco (UCSF), with joint appointments in Anatomy, Psychiatry, and the Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research. He earned his PhD in Biomedical Sciences at the University of Edinburgh and completed postdoctoral training at UCSF before joining the UCSF faculty in 2017.

     

    His research centers on human brain development, particularly cortical neurogenesis and gene regulatory networks, with the overarching goal of establishing the human brain as a primary model system for neuroscience. His lab develops scalable tools to map cell lineage, neuronal fate decisions, and synaptic connectivity in human brain tissue. This work has led to key discoveries, such as redefining the timeline of neuron and glia production and uncovering epigenetic maps of cortical areas.

A/Prof Jerome Mertens - UCSD, San Diego, California, USA

  •  Dr. Jerome Mertens is a stem cell biologist and Associate Professor and Riford Chair for Neurodegenerative Disease and Dementia at the Department for Neurosciences of the University of California San Diego, and Adjunct at the Salk Institute for Biological Studies. He obtained his PhD at the University of Bonn working on induced pluripotent stem cell (iPSC) models for Alzheimer’s Disease with Oliver Brüstle, and continued his research as a postdoc with Rusty Gage at the Salk Institute. Dr. Mertens’ lab focuses on modeling human brain aging and age-related neurodegenerative and other neurological disorders using patient-specific cellular reprogramming models. To study the interface between human biological aging and neurodegeneration, the lab uses direct conversion of human donor fibroblasts into induced neurons (iNs) to generate human patient-specific models that retain important aging information of their donors. Because iPSC reprogramming erases the aging information of somatic cells, the Mertens lab combines iN and iPSC technologies with functional genetics, next-generation sequencing techniques, and other ‘multi-omics’ strategies to complement functional cell biological approaches related to aging and neurodegeneration. The ultimate goal is to better understand age-related disorders via elucidating the interplay between genetic, non-genetic human age-related cellular changes and disease pathways.

A/Prof Silvia Velasco - Murdoch Children’s Research Institute - Melbourne, Australia

  • A/Prof. Silvia Velasco leads the Neural Stem Cells Laboratory at the Murdoch Children's Research Institute and is Principal Investigator at the Novo Nordisk Foundation Center for Stem Cell Medicine, ReNEW, in Melbourne, Australia. Her laboratory uses advanced pluripotent stem cell-derived neural organoid models to study human brain development, understand brain diseases, and develop new and effective therapies. Her research interest in stem cell biology and developmental neuroscience began during her postdoctoral training at New York University and The Broad Institute of MIT and Harvard, in the USA. She completed her Ph.D. in Human Biology at the University of Turin in Italy.

Dr Jennifer Erwin - Aluco Biosciences - Baltimore, USA

  • Dr. Jennifer Erwin is a neuroscientist and translational researcher whose work bridges genetic discovery and therapeutic development in psychiatric and neurodegenerative brain disorders. Her work uses human stem cell–derived organoids to reveal how histone H3K4 methylation and SETD1A drive disease risk in rare patients and to establish their relevance across the broader psychiatric patient population. Beyond discovery, she directs preclinical proof of concept development at Aluco Biosciences, a company developing a small molecule LSD1 inhibitor that normalizes H3K4 methylation for psychiatric indications. Her research integrates molecular neuroscience, stem cell models, and therapeutic innovation to chart new paths from genetic discoveries to patient impact.

A/Prof Chris Bye - Flinders University, SAHMRI, Adelaide, Australia

  • Dr Bye leads the MND Drug Screening & Precision Medicine Program at the Florey Institute of Neuroscience. Focusing on the predominant sporadic form of MND/ALS, his team have generated an iPSC library with over 100 MND lines, recapitulated the hallmark degeneration of motor neurons from sporadic MND donors, and established a large-scale drug screening pipeline to identify and test new therapeutics for people with MND.

Prof Cedric Bardy - SAHMRI, Flinders University, Adelaide, Australia

  • Cedric is an ARC Future Fellow, Matthew Flinders Professor, and group leader at the South Australian Health and Medical Research Institute (SAHMRI) and Flinders University. He currently leads the Laboratory for Human Neurophysiology and Genetics (www.bardylab.com) and serves as the founding Director of the Brain Organoid Therapeutics Screening Platform (www.brainorganoidtherapeutics.com) based at SAHMRI.  

     

    Cedric’s research team focuses on developing therapeutics for adult and pediatric neurodegenerative disorders and brain cancer and plays a pioneering role in advancing human brain models in vitro. Cedric is internationally recognised for inventing BrainPhys™, a widely used neuromedium to culture human brain cells in vitro, and for groundbreaking contributions to using iPSCs to study genetic brain disorders.

Prof Lucy Palmer - The Florey Institute, University of Melbourne, Australia

  • Professor Lucy Palmer is an ARC Future Fellow and NHMRC L1 Investigator who heads the Neural Network Laboratory at the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia.  She completed her Master of Science at the University of Minnesota, Ph.D at the Australian National University, and was a postdoctoral researcher at the University of Bern, Switzerland and Charite University, Berlin. Her research uses single cell imaging and electrophysiological techniques in human and mouse tissue to investigate dendritic integration during memory formation and how neural excitability is influenced by brain cancer. 

Prof Anai Gonzalez-Cordero - Children’s Medical Research Institute, University of Sydney, Australia

  • Associate Professor Anai Gonzalez-Cordero is a Al & Val Rosenstrauss Fellow, and a Group Leader at Children’s Medical Research Institute (CMRI), with a co-joint appointment at The University of Sydney.

    Dr Gonzalez-Cordero is a leader in the field of stem cells and their differentiation into organoids with an emphasis on translational research to develop novel therapies for retinal genetic diseases.

     

    Having started her scientific career in the UK, she obtained a Wellcome Trust PhD in Stem Cell and Developmental Biology and continued her work at the Institute of Ophthalmology, University College London. In 2019, Dr Gonzalez-Cordero relocated to Australia to continue her research programme in stem cells and ophthalmology. Her work in the field has led to numerous awards, including the MetCalf Prize for Stem Cell Research in 2022, and high impact studies including proof-of-concept studies for stem cell-based cell therapy by transplantation of the light sensing cells, the photoreceptor cells, which once in the eye can rescue vison perception in blind animal models.

     

    Anai is a Board member for Retina Australia, the current Vice-President of the Australasian Society for Stem Cell Research (ASSCR) and a founding member of the NSW Organoid Innovation Centre and the Non-Animal technologies Network (NAT-Net). At CMRI she also heads the Stem Cell and Organoid Facility proving iPSC lines and human organoid models for Australian researchers.